Pharmacokinetics of drugs following iv bolus, iv infusion, and oral. In the general case, of noncommensurateorder systems, a different approach. A single compartment simulation model of pharmacokinetics. This paper proposed an important approach to transform published non compartment model pharmacokinetics pk parameters into compartment. The fundamental principles of compartmental pharmacokinetics. Compartmental model a compartment is a group of tissues with similar blood flow and drug affinity. This paper proposed an important approach to transform published noncompartment model pharmacokinetics pk. The method one actually employs depends on what is required from the analysis. Contents of the powerpoint on non compartmental pharmacokinetics include. Non compartment model to two compartment model transformation. Pharmacokinetics model is the central piece of model based drug development. Noncompartment pharmacokinetics is a new approach devised to study the time course of drug in the body with out assuming any compartment model. This paper proposed an important approach to transform published noncompartment model pharmacokinetics pk parameters into compartment.
Pharmacokinetic data analysis has been increasingly utilized since this approach permits the analysis of data without the use of a specific compartment model. A first course in pharmacokinetics and biopharmaceutics. When analyzing pharmacokinetic data, one generally employs either model fitting using nonlinear regression analysis or noncompartmental analysis. A much more uptodate version of this course is available at basic pharmacokinetics. Phar 7633 chapter 21 non linear pharmacokinetic models scheme or diagram diagram 21.
If neither is possible, it is still possible to exploit the special features of the compartmental equations to give bounds on the values for the rate constants chau. Model independent method overcomes some of the drawbacks associated with classical compartment modeling. This noncompartment model pk parameter transformation into compartment model metaanalysis approach possesses valid. Analysis of the drug kinetic in the body may be compartmental or noncompartmental. Body weight was the best predictor in parameter models for all model parameters cl, q, v1 and v2.
Noncompartment model to compartment model pharmacokinetics. Introduction to noncompartmental pharmacokinetic approach differences between compartment and noncompartment models concepts of noncompartmental model statistical moments theorymean residence time different pharmacokinetic parameters in noncompartment model noncompartment pharmacokinetics is a new approach devised to. The dynamics of drug absorption, distribution, metabolism and elimination. Non compartment model to compartment model pharmacokinetics transformation metaanalysis a multivariate nonlinear mixed model. Chapter 16 non compartmental analysis johan gabrielsson and daniel weiner abstract when analyzing pharmacokinetic data, one generally employs either model. Compartment is the traditional and most widely used approach to pharmacokinetic characterization of drug. Compartmental and noncompartmental pharmacokinetic. Compartmental modeling describes the movement of a substance from one compartment to another. Phar 7633 chapter 21 nonlinear pharmacokinetic models. A first course in pharmacokinetics and biopharmaceutics david bourne, ph. Describe the differences between manual noniterative curve fitting and. Compartmental and noncompartmental pharmacokinetic analysis. One compartment open model, extravascular administration, firstorder absorption. If a drugs pharmacokinetics follows a two compartment model with oral dose 5, the following non compartment model pk parameters, w vd, auc, t max, cl iv, t 12,slow, t 12,fast, are necessary to recover the two compartment model parameters.